11th Symposium on Advances in Cancer Immunology & Immunotherapy

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Chairs: C.N. Baxevanis (GR), M. Goulielmaki (GR)
08.40-09.00 B-cell immunity in Cancer P. Lehmann (US)
09.00-09.20 Decoding immune escape: the basis for advancing
(immuno) therapies B. Seliger (DE)
09.20-09.40 Discussion

Chairs: B. Seliger (DE), I. Nikas (CY)
10.00-10.20 Pre-existing Antitumor Immunity in NSCLC A. Xagara (GR)
10.20-10.40 Non-alcoholic steatohepatitis to hepatocellular carcinoma:
the role of inflammation Α. Chatzigeorgiou (GR)
10.40-11.00 Modulating fibroblast populations in pancreatic cancer - implications
on the immune microenvironment D. Öhlund (SE)
11.00-11.20 Discussion

Chairs: S. Karagiannis (UK), C. Gouttefangeas (DE)
11.20-11.40 Decoding the Immune Microenvironment:
Crossroads of Infection and Cancer T. Frisan (SE)
11.40-12.00 Microbiota-gut-brain axis in glioblastoma? O. Martin (FR)
12.00-12.20 Discussion

Chairs: J. Wischhusen (DE), A. Xagara (GR)
1. CONTEXT-DEPENDENT ROLE OF AUTOPHAGY IN COLORECTAL CANCER:
PROGNOSTIC SIGNIFICANCE, THERAPEUTIC IMPLICATIONS, AND CROSSTALK
WITH DRUG RESISTANCE PATHWAYS E. Koustas
2. EFFECT OF DIFFERENT CYTOKINES ON PD-L1 AND HLA-CLASS-I EXPRESSION IN
LUNG CANCER CELL LINES E. Xanthopoulou
3. EFFECT OF G-CSF ON LYMPHOCYTE COUTNS AND CD8+ LYMPHOCYTES
IN LUNG CANCER PATIENTS UNDERGOING CHEMO-RADIOTHERAPY I. Koukourakis
4. IMMUNE LANDSCAPE AND MICROBIOME-ASSOCIATED SIGNATURES IN PANCREATIC
DUCTAL ADENOCARCINOMA: INSIGHTS FROM MURINE AND ORGANOID MODELS V. Vardas
5. MECHANISTIC INSIGHTS INTO CREB1 REGULATION BY miR-128-3p IN
HER2-POSITIVE BREAST CANCER D. Kokoretsis
6. IN-DEPTH CHARACTERIZATION OF CIRCULATING EXHAUSTED AND
REGULATORY T-CELLS IN COLORECTAL CANCER PATIENTS K. Vasilieva
7. ACTIVITY TESTING OF DIFFERENTLY PRODUCED PREPARATIONS OF GDF-15 T. Hanso

Chairs: T. Frisan (SE), L. Conti (IT)
14.40-15.00 Challenges in the Development of an Academic CAR-T Cell Program
in Emerging Countries A. Madrigal (UK)
15.00-15.20 Lessons from pregnancy for immunomodulation in
cancer and autoimmunity J. Wischhusen (DE)
15.20-15.40 T cell therapy in melanoma Ε.M. Inderberg (NO)
15.40-16.00 Discussion

Chairs: C.N. Baxevanis (GR), Ε.M. Inderberg (NO)
16.20-16.50 Identification of T cell target antigens in
small cell lung cancer C. Gouttefangeas (DE)
16.50-17.20 Systemic immune response in pancreatic cancer - potential role
for immunotherapy L. Bojmar (SE)
17.20-17.50 Toll-like Receptor 2-Targeted Therapies Enhance Chemotherapy
and Immunotherapy Efficacy in Breast Cancer L. Conti (IT)
17.50-18.20 Discussion

Chairs: Κ. Dimitropoulos (GR), F. Koinis (GR)
18.30-18.50 Immunotherapy in urothelial carcinomas F. Koinis (GR)
18.50-19.10 Advances in immunotherapy in renal cell carcinoma P. Vlachostergios (GR)
19.10-19.30 Discussion

Chairs: S. Karagiannis (UK), J. Wischhusen (DE), I. Pateras (GR), T. Frisan (SE)

Chairs: C. Gouttefangeas (DE), J. Wischhusen (DE)
08.40-09.00 Decoding the Tumor Microenvironment: Analysis of
Multiple Biomarkers in Human Tissues Il. Nikas (CY)
09.00-09.20 CTCs pancreas - Circulating Tumor Cells (CTCs) and immune
checkpoints molecules; Clinical relevance and perspectives G. Kallergi (GR)
09.20-09.40 Emerging Immune Biomarkers in Prevalent Solid Tumors I. Pateras (GR)
09.40-10.00 Advancing cancer diagnosis and prognosis with
spatial transcriptomics and AI A. Giakountis (GR)
10.00-10.20 Discussion

Chairs: G. Kallergi (GR), I. Pateras (GR)
10.50-11.10 Allotypic variation in antigen presentation regulates
the immunopeptidome of cancer cells E. Stratikos (GR)
11.10-11.30 Design of monoclonal antibody therapies for solid tumours through
the study of patient immune responses S. Karagiannis (UK)
11.30-11.50 Discussion

Chair: A. Giakountis (GR), A. Xagara (GR)
1. WHOLE EXOME SEQUENCING OF A RARE SUBTYPE OF INVASIVE
LOBULAR CARCINOMA N. Koufopoulos
2. SPATIAL ANALYSIS AND PROGNOSTIC IMPACT OF TILs IN
OPERABLE NON-SMALL CELL LUNG CARCINOMAS K. Ntostoglou
3. IMMUNE-RELATED GENE SIGNATURES WITH PROGNOSTIC POTENTIAL IN
PATIENTS WITH HEAD AND NECK CANCER P. Batsaki
4. T-CELL IMMUNITY TOWARDS HER-2/neu IN PATIENTS WITH BREAST CANCER E. Mitsaki

Chairs: V. Georgoulias (GR), T. Frisan (SE)
Immunotherapy in breast cancer past present future - beyond triple negative? J. Bergh (SE)

Chairs: E. Stratikos (GR), S. Karagiannis (UK)
14.00-14.20 The role of T cells as biomarkers in cancer M. Goulielmaki (GR)
14.20-14.40 Dissecting the tumor microenvironment in early breast cancer:
clinical implications and novel insights A. Matikas (SE)
14.40-15.00 Targeting TNF Receptors for Tumor Therapy A. Beilhack (DE)
15.00-15.20 The Role of Epigenetic Modulation in Tumorigenesis? V. Anastasopoulou (GR)
15.20-15.40 Discussion

Chairs: V. Papadopoulos (GR), E. Zafeiriou (GR)
15.40-16.10 10 years of Immunotherapy in Melanoma A. Laskarakis (GR)
16.10-16.40 Immune Checkpoint Blockade in Melanoma - Past, Present and Future A. Selvan
Sponsored Lecture
16.40-17.00 Discussion

Chairs: A. Kotsakis (GR), K. Tsapakidis (GR)
17.15-17.45 Reinforcing therapeutic options for patients with NSCLC and PD-L1
positive expression without driver mutations I. Mountzios (GR)
Sponsored Lecture
17.45-18.15 Shaping the Future of resectable NSCLC:
Exploring the latest Therapeutic Strategies A. Bokas (GR)
Sponsored Lecture
18.15-18.45 Bridging the gap with dual immunotherapy in
patients with metastatic NSCLC and low PD-L1 expression D. Ziogas (GR)
Sponsored Lecture
18.45-19.00 Discussion

Chair: V. Georgoulias (GR), E. Saloustros (GR)
19.20-19.40 Novel therapeutic approaches in gynecological cancer M. Liontos (GR)
19.40-20.00 MTAP deleted cancers K. Leventakos (US)

Chair: A. Kotsakis (GR), V. Georgoulias (GR)
Pathology in the era of precision oncology P. Foukas (GR)

Chairs: S. Karagiannis (UK), J. Wischhusen (DE), I. Pateras (GR), T. Frisan (SE)

Chairs: G. Samaras (GR), F. Koinis (GR)
08.40-09.00 IO in cholangiocarcinoma G. Oikonomopoulos (GR)
09.00-09.20 IO in gastric and gastroesophageal carcinoma A. Stribakos (GR)
09.20-09.40 IO in colorectal carcinoma G. Papaxoinis (GR)
09.40-10.00 Discussion

Chairs: A. Kotsakis (GR), V. Papadopoulos (GR) Recent updates in resectable Locally Advanced Head and Neck cancer E. Sogka (GR)

Chairs: A. Kotsakis (GR), V. Papadopoulos (GR)
HLA-class-I expression loss in cancer and therapeutic restoration:
the role of Radiotherapy and Autophagy M. Koukourakis (GR)

Chairs: S. Karagiannis (UK), J. Wischhusen (DE), I. Pateras (GR), T. Frisan (SE)

Anastasopoulou V.
Postdoctoral Researcher, Hellenic Oncology Research Group, Athens, Greece
Baxevanis K.
Scientific Director, Cancer Immunology and Immunotherapy Center “Agios Savvas”, Hospital, Athens, Greece
Beilhack A.
Professor, Head of the Interdisciplinary Center for Clinical Research Laboratory for Experimental Stem Cell Transplantation, Department of Medicine II & University Children’s Hospital Center for Experimental Molecular Medicine, Würzburg, Germany
Bergh J.
MD, PhD FRCP, Professor of Oncology, Karolinska Institutet, co-Chair EBCTCG, Visiting Professor, Oxford University, Cancer Research Karolinska Institutet and Karolinska Comprehensive Cancer Center (KCCC), Senior Consultant in Oncology, Breast Cancer Center, KCCC & University Hospital, Board Member Karolinska CCC, Stockholm, Sweden
Bojmar L.
Assistant Professor, Docent, Department of Biomedical and Clinical Sciences (BKV), Division of Surgery, Orthopedics and Oncology (KOO), Linköping University, Linköping, Sweden
Bokas A.
Medical Oncologist, 1st Medical Oncology Dpt., Theagenio Cancer Hospital of Thessaloniki, Greece
Chatzigeorgiou A.
BSc, MD, PhD, Associate Professor of Experimental and Clinical Physiology, Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Conti L.
Assistant Professor in Immunology and General Pathology, Department of Molecular Biotechnology and Health Sciences, University of Turin, c/o Molecular Biotechnology Center, OncoImmunology group, Italy
Dimitropoulos K.
MD, PhD, FEBU, Assistant Professor of Urology, School of Medicine, University of Thessaly, Greece, Honorary Consultant Robotic Surgeon, Aberdeen Royal Infirmary, Department of Urology, Scotland, UK
Foukas P.
MD, Associate Professor, 2nd Department of Pathology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
Frisan T.
Professor, Department Molecular Biology, Umeå Centre for Microbial Research (UCMR), Umeå University, Sweden
Georgoulias V.
Professor Emeritus of Medical Oncology, University of Crete, Heraklion, Greece
Giakountis A.
Assistant Professor, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Goulielmaki M.
PhD, Post-doctoral Researcher, Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, Greece
Gouttefandeas C.
Professor, Group leader at the Institute for Immunology, Tübingen, Germany
Inderberg E.M.
Department of Cellular Therapy, Oslo University Hospital - The Norwegian Radium Hospital, Oslo, Norway
Kallergi G.
Associate Professor of Biochemistry, Department of Biology, University of Patras, Greece
Karagiannis S.
Professor of Translational Cancer Immunology and Immunotherapy, St. John’s Institute of Dermatology, School of Basic & Medical Biosciences , King’s College London, Guy’s Hospital, London, UK
Koinis F.
MD, PhD, Assistant Professor of Medical Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Kotsakis Α.
MD, PhD, Professor of Medical Oncology, Director of Department of Medical Oncology, University Hospital of Larissa, Thessaly, Greece
Koukourakis M.
Radiation Oncologist, Professor, Medical School, Democritus University of Thrace - Head Dept of Radiotherapy - Oncology, Radiobiology and Radiopathology Unit, Universiy Hospital of Alexandroupolis, Greece
Laskarakis A.
Professor, Head of the Nursing Department, International Hellenic University, Thessaloniki, Greece
Lehmann P.
MD, PhD, Professor, Department of Pathology, Case Western Reserve University, USA
Leventakos K.
MD, PhD, Assistant Professor, Chest oncology and clinical studies phase 1, Mayo Clinic, Rochester, USA
Liontos M.
Medical Oncologist, Assistant Professor Dept of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece
Madrigal A.
MD, PhD, FRCP, FRCPath, DSc, HonDSci, FMedSci, Professor of Haematology, UCL Cancer Institute, Honorary Consultant, Royal Free NHS Trust, UCL Country Ambassador for México
Martin O.
PhD, HDR, Associate Professor in clinical microbiology, University of Bordeaux, CNRS U5095, France
Matikas A.
Associate Professor of Oncology, Karolinska Institutet, Stockholm, Sweden
Mountzios I.
Consultant-Medical Oncologist, 2 nd Oncology Department and Clinical T rials Unit, Henry Dunant Hospital, Oncolife Institute Founder
Nikas I.
Assistant Professor of Pathology, European University Cyprus, Nicosia, Cyprus
Öhlund D.
MD, PhD, Assistant Professor, Umeå University, Dept. of Radiation sciences and Wallenberg Centre of Molecular Medicine (WCMM), Sweden
Oikonomopoulos G.
Consultant in Medical Oncology, MSc, 2nd Oncology Department, Metropolitan Hospital, N. Faliro, Greece
Papadopoulos V.
MD, Oncologist, Consultant, Department of Oncology, University Hospital, Larisa, Greece
Papaxoinis G.
MD, PhD, Consultant Medical Oncologist, Agios Savvas Anticancer Hospital, Athens, Greece
Pateras I.
Pathologist, Assοciate Professor, 2nd Department of Pathology, “Attikon” University Hospital, Medical School, National and Kapodistrian University of Athens, Greece
Saloustros E.
MD, PhD, Associate Professor of Medical Oncology, School of Medicine, University of Thessaly, General University Hospital of Larissa, Larissa, Greece
Samaras I.
MD, Medical Oncologist, University Hospital of Larissa, Greece
Seliger B.
Professor of Immunology, Institute of Medical Immunology, Martin - Luther - University Halle - Wittenberg, Halle, Germany
Selvan A.
Director, Melanoma Portfolio / Product Design & Delivery, Worldwide Medical | Oncology, Bristol Myers Squibb
Sogka E.
Medical Oncologist, Consultant of Medical Oncology, Day Care Unit, Papanikolaou General Hospital, Thessaloniki, Greece
Stratikos E.
Associate Professor, Biochemistry Department of Chemistry, National and Kapodistrian University of Athens, Greece
Strimpakos Α.
Medical Oncologist, Director of 5th Internal Medicine - Oncology Clinic Hygeia, Athens, Greece
Tsapakidis K.
Consultant Medical Oncologist, University of Thessaly - Faculty of Medicine, Dpt of Medical Oncology, University Hospital of Larissa, Greece
Vlachostergios P.
MD, PhD, Medical Oncologist, IASO Thessalias General Hospital, Assistant Professor of Clinical Medicine, Weill Cornelll Medical College, NY, USA
Wischhusen J.
PhD, Professor of Experimental Tumor Immunology, University of Würzburg School of Medicine, Department of Gynecology and Obstetrics, Germany
Xagara Α.
PhD, Molecular Biologist, Postdoctoral Researcher, Department of Medical Oncology, University General Hospital of Larissa, Thessaly, Greece
Zafeiriou E.
Associate Professor of Dermatololy, Head of Department of Dermatology, University of Thessaly, University Hospital of Larissa, Greece
Ziogas D.
MD, PhD, Academic Scholar in Medical Oncology, 1st Department of Internal Medicine, Laikon General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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