On Demand | Targeting Homologous Recombination Deficiency in Cancer – From Bench to Clinic 2023

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Registration

Welcome address A. Klinakis (GR)

Chair: V. Georgoulias (GR), Z.Lygerou (GR)

12.00-12.30: Precision Medicine and the ‘‘Genome of Greece” D. Thanos (GR)       

12.30-13.00: Overview of HRD: From the bench to the clinic A. Klinakis (GR)

Light Lunch

Chairs: Th. Rampias (GR), S. Gagos (GR)

14.00-14.20: Mechanisms for DNA damage repair (DDR) D. Karagiannis (US)   

14.20-14.40: Oncogene induced replication stress Z. Lygerou (GR)   

14.40-15.00: Stress-induced senescence and role in tumor growth A. Goutas (GR) 

15.00-15.10: Discussion

Chairs: P. Makrythanasis (GR), A. Voutsina (GR)

15.10-15.30: Mechanisms of tumor efficacy and toxicity by PARP inhibitors T. Halazonetis (CH) 

15.30-15.50: Genomic instability as driver of tumor evolution G. Nasioulas (GR) 

15.50-16.10: Telomeric instability S. Gagos (GR)   

16.10-16.20: Discussion

Coffee Break

Chairs: A. Klinakis (GR), P. Constantoulakis (GR) 

16.40-17.00: Chromosomal aberrations and manifestations of genomic instability S. Gagos (GR)

17.00-17.20: Synthetic lethality and PARP inhibitor technology, parylation Th. Rampias (GR) 

17.20-17.30: Discussion

Chairs: A. Giatromanolaki (GR), C.N. Baxevanis (GR)

17.30-17.50: Tumor microenvironment and immunogenicity I. Pateras (GR)       

17.50-18.10: The heterogeneous molecular landscape of NSCLC P. Foukas (GR) 

18.10-18.30: Heterogeneity of immunotherapy-induced alteration in the tcrb repertoire of NSCLC patients    M. Goulielmaki (GR)       

18.30-18.40: Discussion

Chairs: I. Pateras (GR), G. Nasioulas (GR)

09.00-09.20: The NGS as a diagnostic tool for precision medicine E. Papadopoulou (GR) 

09.20-09.40: HRD scoring platforms (technologies) P. Constantoulakis (GR)   

09.40-10.00: HRD in Comprehensive Genomic Profiling: The Illumina proposal for a complete molecular profile Ch. Magnanini (IT)

10.00-10.20: Non-HRR gene-mediated HRD M. Rubsam (DE)   

10.20-10.40: Revealing the HRD status in NSCLC K. Tsilingiri (GR)   

10.40-11.00: Discussion      

Chairs: V. Georgoulias (GR)

11.00-10.20: Targeting HRD in breast cancer A. Constantinidou (CY)   

10.20-11.40: Targeting HRD in ovarian cancer R. Zakopoulou (GR)   

11.40-12.00: Targeting HRD in prostate cancer and pancreatic cancer M. Liontos (GR)     

12.00-12.20: Targeting HRD in the agnostic treatment setting M. Rovithi (GR)   

12.20-13.00: Discussion  

Coffee Break

Chairs: Α. Klinakis (GR)

13.00-13.20: HRD prevelance in other tumor types G. Christopoulou (GR)   

13.20-13.40: Combination of PARP inhibition with immunotherapy V. Anastasopoulou (DE)   

13.40-14.00: Combination of PARP inhibitors with other treatments O. Fiste (GR)     

14.00-14.20: Mechanisms of resistance to PARP inhibitors Th. Rampias (GR)   

14.20-14.40: Discussion

Concluding Remarks 

Anastasopoulou V.
Postdoctoral Researcher, Hellenic Oncology Research Group, Athens, Greece
Baxevanis C.N.
Scientific Director, Cancer Immunology and Immunotherapy Center “St. Savvas” Cancer Hospital, Athens, Greece
Constantinidou A.
MD, MRCP, MSc, PhD, Medical Oncologist, Medical School University of Cyprus & BoC Oncology Centre, Nicosia, Cyprus
Constantoulakis P.
PhD, Scientific Director, GENOTYPOS MSA
Fiste O.
MD, MSc, PhD, Medical Oncologist, 3rd Department of Internal Medicine and the Affiliated Laboratory, School of Medicine, National and Kapodistrian University of Athens, “Sotiria” Hospital, Athens, Greece
Foukas P.
MD, Associate Professor, 2nd Department of Pathology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
Gagos S.
Principal Investigator Biomedical Research Foundation of the Academy of Athens (BRFAA), Greece
Georgoulias V.
Professor Emeritus of Medical Oncology, University of Crete, Heraklion, Greece
Giatromanolaki A.
MD, Professor of Pathology, Medical School, Democritus Univeristy of Thrace, Alexandroupolis, Greece
Goulielmaki M.
PhD, Post-doctoral Researcher, Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, Greece
Goutas A.
Postdoctoral Researcher, Biomedical Research Foundation of the Academy of Athens (BRFAA), Greece
Halazonetis T.
Professor, Dept of Molecular and Cellular Biology, University of Geneva, Switzerland
Karagiannis D.
Yποψήφιος διδάκτορας στο Τμήμα Γενετικής & Ανάπτυξης, Πανεπιστήμιο Κολούμπια, Tμήμα Ιατρικού Κέντρου του Πανεπιστημίου Κολούμπια (CUMC), Νέα Υόρκη, ΗΠΑ
Lygerou Z.
PhD, Professor, Head, Department of Gener al Biology, Director of Studies, MSc Life Sciences Informatics, School of Medicine, Univ ersity of Patras, Patras, Greece
Makrythanasis P.
MD, PhD, PD, Assistant Professor, Medical Genetics, Laboratory of Medical Genetics, Medical School, National and Kapodestrian University of Athens, Greece
Nasioulas G.
PhD, Chief Scientific Officer, Genekor Medical S.A., Athens, Greece
Rampias Th.
PhD, Investigator - Assistant Professor Level, Biochemical Research Foundation Academy of Athens (BRFAA), Greece
Rubsam M.
Thanos D.
PhD, Member of the Academy of Athens, President of the Scientific Board, Biomedical Research Foundation, Academy of Athens, Greece
Tsilingiri K.
PhD, Cancer Biology Laboratory, Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Greece
Voutsina A.
MSc, PhD, Postdoctoral Researcher, Greek Genome Center, Biomedical Research, Foundation Academy of Athens (BRFAA), Athens, Greece
Zakopoulou R.
MD, PhD, Medical Oncologist, Locum Consultant, General Anticancer Hospital “Agioi Anargyroi”, Athens, Greece

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