On Demand | Targeting Homologous Recombination Deficiency in Cancer – From Bench to Clinic 2023

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Welcome address A. Klinakis (GR)

Chair: V. Georgoulias (GR), Z.Lygerou (GR)

12.00-12.30: Precision Medicine and the ‘‘Genome of Greece” D. Thanos (GR)       

12.30-13.00: Overview of HRD: From the bench to the clinic A. Klinakis (GR)

Chairs: Th. Rampias (GR), S. Gagos (GR)

14.00-14.20: Mechanisms for DNA damage repair (DDR) D. Karagiannis (US)   

14.20-14.40: Oncogene induced replication stress Z. Lygerou (GR)   

14.40-15.00: Stress-induced senescence and role in tumor growth A. Goutas (GR) 

15.00-15.10: Discussion

Chairs: P. Makrythanasis (GR), A. Voutsina (GR)

15.10-15.30: Mechanisms of tumor efficacy and toxicity by PARP inhibitors T. Halazonetis (CH) 

15.30-15.50: Genomic instability as driver of tumor evolution G. Nasioulas (GR) 

15.50-16.10: Telomeric instability S. Gagos (GR)   

16.10-16.20: Discussion

Chairs: A. Klinakis (GR), P. Constantoulakis (GR) 

16.40-17.00: Chromosomal aberrations and manifestations of genomic instability S. Gagos (GR)

17.00-17.20: Synthetic lethality and PARP inhibitor technology, parylation Th. Rampias (GR) 

17.20-17.30: Discussion

Chairs: A. Giatromanolaki (GR), C.N. Baxevanis (GR)

17.30-17.50: Tumor microenvironment and immunogenicity I. Pateras (GR)       

17.50-18.10: The heterogeneous molecular landscape of NSCLC P. Foukas (GR) 

18.10-18.30: Heterogeneity of immunotherapy-induced alteration in the tcrb repertoire of NSCLC patients    M. Goulielmaki (GR)       

18.30-18.40: Discussion

Chairs: I. Pateras (GR), G. Nasioulas (GR)

09.00-09.20: The NGS as a diagnostic tool for precision medicine E. Papadopoulou (GR) 

09.20-09.40: HRD scoring platforms (technologies) P. Constantoulakis (GR)   

09.40-10.00: HRD in Comprehensive Genomic Profiling: The Illumina proposal for a complete molecular profile Ch. Magnanini (IT)

10.00-10.20: Non-HRR gene-mediated HRD M. Rubsam (DE)   

10.20-10.40: Revealing the HRD status in NSCLC K. Tsilingiri (GR)   

10.40-11.00: Discussion      

Chairs: V. Georgoulias (GR)

11.00-10.20: Targeting HRD in breast cancer A. Constantinidou (CY)   

10.20-11.40: Targeting HRD in ovarian cancer R. Zakopoulou (GR)   

11.40-12.00: Targeting HRD in prostate cancer and pancreatic cancer M. Liontos (GR)     

12.00-12.20: Targeting HRD in the agnostic treatment setting M. Rovithi (GR)   

12.20-13.00: Discussion  

Chairs: Α. Klinakis (GR)

13.00-13.20: HRD prevelance in other tumor types G. Christopoulou (GR)   

13.20-13.40: Combination of PARP inhibition with immunotherapy V. Anastasopoulou (DE)   

13.40-14.00: Combination of PARP inhibitors with other treatments O. Fiste (GR)     

14.00-14.20: Mechanisms of resistance to PARP inhibitors Th. Rampias (GR)   

14.20-14.40: Discussion

Anastasopoulou V.
Postdoctoral Researcher Charité - Berlin University Medicine and German Cancer Research Center (DKFZ, Heidelberg), Berlin
Baxevanis C.N.
Scientific Director, Cancer Immunology and Immunotherapy Center “St. Savvas” Cancer Hospital, Athens, Greece
Christopoulou G.
MSc, PhD, Lab Manager, Head of Genetics & Genomics Dpt, Genotypos S.A. / MSc, PhD, Μοριακή Βιολόγος-Γενετιστής, Διευθύντρια Εργαστηρίου, Γενότυπος Α.Ι.Ε
Constantinidou A.
MD, MRCP, MSc, PhD, Medical Oncologist, Medical School University of Cyprus & BoC Oncology Centre, Nicosia, Cyprus
Constantoulakis P.
PhD, Molecular Biologist - Geneticist, Scientific Director, GENOTYPOS M.S.A., Greece
Fiste O.
Fellow in Medical Oncology, Medical Oncology Unit, Department of Clinical Therapeutics, Alexandra Hospital, Athens, Greece
Foukas P.
MD, Associate Professor, 2nd Department of Pathology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
Gagos S.
PhD, Clinical Cytogeneticist Principal Investigator Biomedical Research Foundation of the Academy of Athens (BRFAA), Greece
Georgoulias V.
Emeritus Professor of Medical Oncology, School of Medicine, University of Crete, Heraklion, Crete, Greece
Giatromanolaki A.
MD, Professor of Pathology, Medical School, Democritus Univeristy of Thrace, Alexandroupolis, Greece
Goulielmaki M.
PhD, Post-doctoral Researcher, Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, Greece
Goutas A.
Halazonetis T.
Professor, Dept of Molecular and Cellular Biology, University of Geneva, Switzerland
Karagiannis D.
Yποψήφιος διδάκτορας στο Τμήμα Γενετικής & Ανάπτυξης, Πανεπιστήμιο Κολούμπια, Tμήμα Ιατρικού Κέντρου του Πανεπιστημίου Κολούμπια (CUMC), Νέα Υόρκη, ΗΠΑ
Klinakis A.
PhD, Director of Research - Professor level, Biomedical Research Foundation of the Academy of Athens, Greece
Kotsakis A.
MD, PhD, Associate Professor of Medical Oncology, Director of Department of Medical Oncology, University Hospital of Larisa, Thessaly, Greece
Liontos M.
PhD, Medical Oncologist, Consultant, Department of Clinical Therapeutics, Alexandra Hospital, Athens, Greece
Lygerou Z.
PhD, Professor, Head, Department of Gener al Biology, Director of Studies, MSc Life Sciences Informatics, School of Medicine, Univ ersity of Patras, Patras, Greece
Makrythanasis P.
MD, PhD, PD, Assistant Professor, Medical Genetics, Laboratory of Medical Genetics, Medical School, National and Kapodestrian University of Athens, Greece
Nasioulas G.
PhD, Chief Scientific Officer, Genekor Medical S.A., Athens, Greece
Papadopoulou E.
PhD, Group Leader of Molecular Oncology, Genekor Medical S.A., Athens, Greece
Pateras I.
Bsc, MD, PhD, Pathologist, Assistant Professor, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Rampias Th.
PhD, Μοριακός Βιολόγος, Ερευνητής Γ’, Ίδρυμα Ιατροβιολογικών Ερευνών Ακαδημίας Αθηνών (ΙΙΒΕΑΑ)
Rovithi M.
Medical Oncologist, Agios Nikolaos General Hospital, Crete, Greece
Rubsam M.
Thanos D.
PhD, Member of the Academy of Athens, President of the Scientific Board, Biomedical Research Foundation, Academy of Athens, Greece
Tsilingiri K.
PhD, Cancer Biology Laboratory, Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Greece
Voutsina A.
MSc, PhD, Postdoctoral Researcher, Greek Genome Center, Biomedical Research, Foundation Academy of Athens (BRFAA), Athens, Greece
Zakopoulou R.
MD, PhD, Medical Oncologist, National and Kapodistrian University of Athens, 2nd Propaedeutic Department of Medicine, A TTIKON University Hospital, Athens, Greece

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